Do NOT use Anafranil if:
- you are allergic to any ingredient in Anafranil or to similar medicines
- you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days, or you are taking astemizole or terfenadine
- you are recovering from a recent heart attack
Contact your doctor or health care provider right away if any of these apply to you.
Before using Anafranil:
Some medical conditions may interact with Anafranil. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you drink alcohol-containing beverages daily or have a history of alcohol abuse
- if you take thyroid medicine or have a history of an overactive thyroid
- if you have a history of adrenal gland problems, glaucoma, heart problems, kidney or liver problems, diabetes, seizures, trouble urinating, the blood disease porphyria, or other blood problems
- if you have a history of suicidal thoughts or behavior, bipolar disorder, or any other mental disorders
- if you are undergoing electroshock therapy or you are scheduled to have any surgery
Some MEDICINES MAY INTERACT with Anafranil. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Azole antifungals (eg, fluconazole), cimetidine, duloxetine, haloperidol, methylphenidate, mibefradil, phenothiazines (eg, chlorpromazine), selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), terbinafine, or valproic acid because they may increase the risk of Anafranil’s side effects
- Astemizole, furazolidone, ketolide antibiotics (eg, telithromycin), macrolide antibiotics (eg, erythromycin), MAOIs (eg, phenelzine), pimozide, or terfenadine because the risk of high blood pressure, serious heart problems (eg, irregular heartbeat), or seizures may be increased
- Barbiturates (eg, phenobarbital) or phenytoin because they may decrease Anafranil’s effectiveness
- Anticoagulants (eg, warfarin), carbamazepine, or sympathomimetics (eg, phenylephrine) because the risk of their side effects may be increased by Anafranil
- Clonidine, guanethidine, or guanfacine because their effectiveness may be decreased by Anafranil
This may not be a complete list of all interactions that may occur. Ask your health care provider if Anafranil may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.